化學名

Thiazolidinedione

[商品---廠商]

Troglitazone [Rezulin-Parke Davis ] [Noscal,Prelay-三共]

Pioglitazone [Actos-Takeda Pharmaceutical America ]

藥理分類

New Oral hypoglycemia agents,Insulin sensitizer,Glitazone,

Thiazolidinedione

治療分類

Hypoglycemic agents

作用機轉

Increased Insulin sensitivity;Decreased Insulin resistance

PPARs [Peroxisomal-proliferator-activated receptors] activation

適應症

Type 2 Diabetes

一般劑量

Troglitazone 400mg QD

Rosiglitazone 4mg QD;2mg BID

Pioglitazone 15-30mg QD

備註

•Troglitazone 因 Syncratic hepatocellular injury 導致61人死亡

•FDA approve: Troglitazone 85.7.30;Rosiglitazone 89.5.25.

•FDA 89.3.21.下令市場回收Troglitazone

•Rosiglitazone ,Pioglitazone 目前無發現類似Troglitazone

肝損傷之情事